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Mylan and Apotex both alleged that the later patent was invalid for obviousness-type double-patenting over the earlier one. Nexium (esomeprazole): This patent expired in May 2014. Innovator AstraZeneca granted a license to Teva (TEVA) to produce the generic form in the United States. The number of discipline review letters has also increased from a low of 35 in January to a high of 224 just two months later and a near-high of 216 in May. Shares of Eli Lilly have outperformed the Zacks classified Large Cap Pharmaceuticals industry so far this year. Absolutely. The FDA says that they can't guarantee the \"quality\" of the drugs from Canada, that these drugs might be dangerous, that they might have been poorly manufactured or improperly formulated, or manufactured in facilities in Southeast Asia. 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